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If left untreated, a B12 deficiency can lead to more severe health issues, including neurological damage

However, as with any medical treatment, some individuals may experience mild to moderate reactions

The dosage of B12 required depends on three key factors

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In addition, tumor-associated intrinsic pathways such as MAPK/PI3K , WNT/-catenin , and PD-1 are closely associated with tumor angiogenesis, and interactions among these pathways affect DC maturation, and T-cell recruitment and activation, and subsequently promote drug resistance in breast cancer