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In addition, certain ART drugs, especially early nucleoside reverse transcriptase inhibitors, inhibit polymerase , driving mtDNA depletion and mutation accumulation that underlie toxicities such as lipodystrophy, neuropathy, and accelerated aging

Interestingly, some drugs based on the study of the regulatory mechanisms of ferroptosis in ovarian diseases, such as cryptotanshinone, N-acetylcysteine, rutin etc., has significantly improved ovarian function