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Zhuang Y, Xu Z, Frederick B, de Vries DE, Ford JA, Keen M, et al

10.1007/s00776-014-0633-0 J Orthop Sci

Conclusion The past two decades have witnessed a paradigm shift in the study of MuSC aging, fueled by continuous advances in transcriptomic technologies and the analytical frameworks built around them

Tree Physiol 43:10091022

It is still unclear whether mHTT initiates ferroptosis by suppressing ferroportin or activating NCOA4-mediated ferritinophagy to disrupt striatal iron homeostasis, nor is it known how lipid peroxidation products generated during ferroptosis (such as 4-HNE) modify mHTT to accelerate its nuclear aggregation and toxic propagation