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Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1 Biophys

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Moreover, iron overload-induced DNA demethylation promotes the expression of nuclear factor erythroid 2-related factor 2 (NRF2) targets, such as NQO1 (NAD(P)H quinone dehydrogenase 1) and GPX2, which subsequently contribute to cellular lipid peroxidation and ferroptosis[113]