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For example, a healthy person taking a 500 mcg oral B12 supplement will only absorb about 10 mcg

Pierre-Eugene C, Pagesy P, Nguyen TT et al (2012) Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2

Without intrinsic factor, the ileum can no longer absorb the B 12

Other Drugs That Affect Vitamin B12: Metformin users may also take other medicines that can decrease vitamin B12 levels

There is now more discussion of this purpose in the discussion section

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