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Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

Red flags that require medical evaluation A sustained resting heart rate above 100 beats per minute (tachycardia) at rest is never normal and should prompt medical evaluation regardless of the cause

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Preclinical models indicate that co-administration of the Nrf2 inhibitor Brusatol with corticosteroids reduces iron overload and lipid peroxidation