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CRISPR/Cas9-mediated knockout of autophagy regulators ATG5/ATG7 in RPMI-8226 MM cells significantly increased cell viability compared to wild-type controls upon RSL3-induced ferroptosis, confirming autophagys synergistic role in ferroptotic execution ( 6.5 Other regulatory mechanisms The interplay between ferroptosis and epigenetic regulation has garnered increasing attention due to their shared associations with oxidative stress and dysregulated iron metabolism

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Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5UTR

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BSPs pretreatment can inhibit the increase of Keap1 protein induced by p31-43, activate antioxidant genes through Nrf2 protein, improve the activity of the antioxidant enzyme, alleviates glutathione redox cycle imbalance, promote the expression of GCLC or GCLM, and reduce oxidative damage