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While some may be concerned that MN penetration increases the risk of deeper tissue, its insertion depth is limited and skin defects caused by MNs will be closed within hours thus reducing the risk of infection

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hence, addition of intrinsic factor in the second step results in an increase in vitamin B 12 absorption (over the baseline established in the first)

10.1016/j.joim.2020.01.008 55 LanT.HuL.SunT.WangX.XiaoZ.ShenD.et al (2023)

Griesinger G, Felberbaum R, Diedrich K