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Biofilms are clusters of different types of bacteria wrapped in a self-produced extracellular matrix that can bind to various surfaces and play an important role in antibiotic resistance

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A full synthesis of translational and clinical implications is organized in Table 4, with riskbenefit interpretation visually supported in Figure 4

In addition to these direct cytotoxic effects of MPO activity, elevated MPO activity increases reactive oxygen species (ROS) formation, MMP activation, and the production of inducible NO synthase, and inflammatory cytokines (i.e., IL-1 and tumor necrosis factor-) (Ekdahl et al., 2003