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1 Introduction Pathophysiology research and drug development both heavily rely on robust in vitro models

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Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

In this study, the team chose to investigate the role of a neurotransmitter called vasoactive intestinal peptide, as it has previously been linked to anti-inflammatory effects, meaning it could have a protective effect on disc tissue

To that end, an E3 ligase activity-deficient mutant of UBR5 was generated by mutating the critical residue cysteine 2768 to alanine (UBR5C2768A, Mut-UBR5), as previously reported 39

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