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Moreover, osteocalcin inhibits cholinergic activity in postganglionic parasympathetic neurons through its receptor, G protein-coupled receptor (GPCR) 6a, thereby enhancing the acute stress response (ASR) in animals, suggesting its role as a stress hormone regulating neural activity under danger (73)

These activated JAKs then phosphorylate STAT proteins, which then translocate to the nucleus where they regulate a set of gene transcription

The threshold for statistical significance was set at a P-value of less than 0.05

There were insignificant changes of some inflammatory markers in some studies, which might be related with short trial duration and inadequate weight loss (6)

H.NadeemM.et al

10.1186/1750-1326-8-28 Mol