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IM and SC routes are increasingly favored due to ease of administration , shorter procedure time, and patient tolerance

doi: 10.2337/dc13-0989 16

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Dermatological factors such as the superficial location of vascular structures, hemosiderin accumulation, and dermal melanocytosis play a role in the formation of dark circles around the eyes

The experimental group of mice was placed in a sleep deprivation device, stay up 20 h a day, rest 4 h, for 4 days, then rest 2 days, according to this schedule for four consecutive times