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3.15 Traumatic brain injury Globally, TBI is the leading cause of death, and more than 60 million people experience TBI each year (Turner et al., 2021)

3.2 Metformin inhibits the TGF-1/Smad3 pathway Another mechanism of HSC activation is the cooperation of TGF-1-related signaling pathways and other signals, including ROS, PDGF, and connective tissue growth factors (66)

Metabolism 286 (3), E463E471

Additionally, axonal mitochondria regulate calcium homeostasis through local interactions with the endoplasmic reticulum