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Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease

A precursor for cellular methylation reactions, methionine plays an important role in lipid metabolism, polyamine synthesis, immune function, heavy metal chelation, and maintenance of redox balance.4 Conversely, dietary methionine restriction in rodents increased energy expenditure, improved insulin resistance, and enhanced lipolysis and fatty acid oxidation in adipose tissue.5 The lipotropic effects of methionine may be attributed to its metabolite S-adenosyl methionine (SAM)

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, et al