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Therefore, scopolamine treatment model has its advantage over other models (Especially a single IP injection of scopolamine) as suitable for POD study, while abdominal surgery in animal may be the proper and widely adopted method in developing POCD as supported by the previous studies 23,24 , but lacks the definite explanation for POD development

Cancer is known for its ability to evade the cell cycle regulatory events and involves abnormalities in extracellular signaling, transcellular transduction, and intracellular networking