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In addition, the Nrf2/HO-1 and HO-1/PGC-1 pathways are recognized as critical components of intracellular signaling cascades involved in neurogenesis and mitochondrial biogenesis

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then, the active receptors can be recycled to the surface of the cytomembrane [90,95]

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In the heterologous expression system HKT proteins are placed into two groups: one as Na + transporters and second as K + transporter (Horie et al., 2007)