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Compared to the other GPXs family, GPX4 possess a broader substrate specificity, and play a vital role in early mouse development, and its involvement in an impressive variety of biological processes [63]

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Catalase also complements GPx by handling high hydrogen peroxide concentrations in peroxisomes, while GPx manages lower levels elsewhere

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154 PNPLA2 homozygous mutations are associated with neutral lipid storage disease and fatty liver