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Disruptions in any of these systems can lead to the accumulation of misfolded, damaged, or aggregated mitochondrial proteins, ultimately causing cellular dysfunction and contributing to diseases such as mitochondrial myopathies and cardiomyopathies 10,11,12

Lys105 is a GSH and enzyme activator in the GSSCys assay In a first set of experiments, we analysed the effects of the Lys105 replacements on the steady-state kinetics at variable GSSCys and GSH concentrations

And you're being aggravated because why

doi: 10.1038/nature25986 79 WeissJMDaviesLCKarwanMIlevaLOzakiMKChengRYet al

Both SOD-dependent agents, SOD@ARA290-HBc and pMnSOD, leverage SODs direct antioxidant activity within a bioengineered vessel to improve drug delivery [69, 77]