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Role of BMAL1 in macrophages The activity of macrophages exhibits a distinct circadian rhythm, and approximately 8%-15% of genes in macrophages display circadian oscillations

Activated PERK inhibits global translation by phosphorylating eukaryotic translational initiation factor 2 alpha (elF2), resulting in promoting the restoration of ER homeostasis (42)

Msaouel P, Yu K, Yuan Y, Chen J, Yan X, Karki M, Duan F, Sheth RA, Rao P, Sircar K, Shah AY, Zurita AJ, Genovese G, Li M, Yeh CC, Dang M, Han G, Chu Y, Hallin M, Olson P, Yang R, Slavin D, Der-Torossian H, Chin CD, Tannir NM, Wang L , Gao J