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Elevated GPX4 also attenuates NF-B activation (208) and suppresses fibroblast IL-6 release (209), mitigating fibrosis

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Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease

279 Furthermore, aging can drive oxidative stress, 280 DNA damage, 281 epigenetic modifications, 282 and mitochondrial dysfunction, 283 which can also contribute to the accumulation of A plaques and tau tangles