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Determinants of outcome: where, when, how much Outcome is governed by three non-independent axeswhere, when and how much: where the ROS originate and in which compartment (e.g., NOX microdomains versus mitochondria and ER versus peroxisome) sets the immediate molecular targets and the surrounding antioxidant context that shapes reactivity (To et al

Humans cannot synthesise biotin so it has to come from the diet

Detailed understanding of the inhibitory action exerted by targeted RTK inhibitors including those affecting the HGF/c-Met signaling is critical for the durable antitumor responses

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