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Lipid analysis of epidermal and dermal cell membranes showed that they contain twelve types of these compounds, including phospholipids, such as phosphatidic acid (PA), phosphatidylethanolamines (PE), cardiolipins (CL), phosphatidylserine (PS), lysophosphatidylcholines (LPC), phosphatidylinositols (PI), alkylacylglycerophosphocholines (AAPC), plasmalogen ethanolamines (Epla), and phosphatidylcholines (PC), as well as sphingolipids (SP), such as dihydrosphingomyelins (DHSM), sphingomyelins (SM), and ceramides (Cer) [13, 35]

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However, considering that the hiPSC-derived neurons are cultured in the presence of a higher concentration of glutamine (2 mM) than that used during the incubation experiments (0.5 mM), it is plausible that increased glutamine metabolism in FTD3 neurons is a compensatory mechanism to fuel mitochondria and potentially accelerate ROS production

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