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Beack et al

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We have recently written about the presence of CD163 in the kidneys of patients and experimental models of rhabdomyolysis.35 Since the anti-inflammatory and antioxidant functions of CD163 are well known, these data suggest that CD163 could play a nephroprotective role in response to the renal accumulation of haemoproteins

Specifically, moderate DNA damage stress triggers mitophagy to remove damaged and depolarized mitochondria, while drastic stress is able to induce mitochondrial outer membrane permeabilization and apoptosis [174]

For instance, emerging research suggests that elevated body fat percentage in conjunction with low lean muscle masscalled sarcopenic obesityis associated with poor kidney-related health outcomes

Moreover, the majority of the itaconated secreted proteins (70%) are annotated as secretory proteins 36 , suggesting that PBSP also has high specificity for protein secretion (Fig