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For example, luteolin, a plant-derived flavonoid, downregulates the proinflammatory cytokines in macrophages and inhibits the production of nitric oxide and pro-inflammatory arachidonic acid by blocking the nuclear factor B (NF-B) signaling pathway (174)

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Other nodules appear to be cold because they lack peroxidase (15)

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The underlying mechanism is often on-target, off-tumor inhibition of EGFR signaling in keratinocytes, which disrupts skin barrier function and epidermal homeostasis