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2.3.1 Inflammatory cytokines and myocardial suppression During sepsis, macrophages sensing PAMPs via PRRs (e.g., TLR4) activate key signaling pathways such as NF-B and mitogen-activated protein kinase (MAPK), driving the synthesis and release of large quantities of pro-inflammatory cytokines (TNF-, IL-1, IL-6) (3638)

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Accordingly, various types of nerve cells strategically coordinate functions to contribute to the collective well-being of the nervous system

Cain KC, Headstrom P, Jarrett ME, Motzer SA, Park H, Burr RL, et al

Redox Biol 53:102345

Oncotarget 6 , 1182011832 (2015)