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It occurs naturally in human plasma at concentrations that decline with age and has been extensively studied in skin biology, wound healing, antioxidant, and gene expression research

doi: 10.1111/j.1567-1364.2009.00593.x 42 CannonR

Genome 61:311322

[DOI] [PubMed] [Google Scholar] Devasani K., Majumdar A

Although the precise molecular mechanisms remain largely elusive, we will describe how ceramides target mitochondria function in brain by several mechanisms: (1) changes in the lipid composition of the mitochondria membrane, (2) alteration in mitochondrial respiratory chain activity and increased in ROS production, and (3) changes in mitophagyapoptosis process

STZ-treated mice are more susceptible to ferroptosis of neurons and a decline in neurological function 77