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The cytotoxicity induced by chemotherapeutic drugs such as 5-FU, oxaliplatin, and paclitaxel is linked with elevated ROS, 175,176,177 and depletion of intracellular GSH using RNAi against the anti-oxidant transcription factor Nrf2 leads to increased ROS and increased sensitivity to chemotherapy in preclinical studies

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Anderson Cancer Center, Houston, TX, 1995 - 1996 Clinical Instructor, Surgery, University of California, Los Angeles, CA, 1993 - 1994 Administrative Appointments/Responsibilities Division Head, Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2014 - Present Department Chair ad interim, Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2015 Division Head ad interim, Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2014 Steering Committee Member, Thoracic and Cardiovascular Surgery, Institute of Personalized Cancer Therapy, Houston, TX, 2008 - 2013 Jr

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