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The sustained levels may also increase the likelihood of certain side effects, particularly joint stiffness and water retention

Not only is APAP overdose a clinically relevant model to study hepatocyte cell death and liver injury, but it is also increasingly used to test potential therapeutic intervention strategies

217 Metal-free NPs/MSNs nanocomposites Among the non-metallic elements, two elements, carbon and phosphorus, can be used to construct carbon-based nanomaterials (e.g., graphene, 218,219,220 carbon dots, 221,222,223 carbon nanotubes 224,225,226 and amorphous carbon 227,228,229 ) and black phosphorus (BP), 230,231,232 respectively, resulting in metal-free NPs/MSNs nanocomposites (Fig