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Segerlantz M, Bramnert M, Manhem P, Laurila E, Groop LC

Theoretical concerns about chronic NNMT inhibition include effects on the metabolism of other quinolinium and methylpyridinium endogenous metabolites and on the broader cellular methylation landscape

Research shows the compounds direct effect on circadian gene expression can help scientists understand how temporal metabolic regulation affects overall health

It tends to upregulate genes involved in regeneration and downregulate those associated with inflammation or fibrosis