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We used our model to test the importance of glucoronidation and its sensitivity to the activity of the glucoronosyl tranferase enzymes by computing the amount of liver damage resulting from a moderate overdose (10 g) with different choices for the V max values of the glucoronosyl tranferases

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Detailed analysis included examining messenger RNA (mRNA) levels for enzymes potentially involved in the liver's urea cycle

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Cheedella NKS, Suzuki A, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Maru DM, Vaporciyan AA, Mariel Taketa T, Blum MA, Welsh J, Lin SH, Lee JH, Bhutani MS, Weston B, Walsh GL, Swisher SG , Ajani JA

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