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It encodes a cell surface molecule that, upon ligand binding, undergoes multiple enzymatic cleavages to generate the NOTCH Intracellular Domain (NICD), which translocates to the nucleus and joins a molecular complex that regulates transcription [12, 13]

Geneva, Switzerland: Department of Environment, Climate Change and Health (ECH)

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Concurrently, pro-inflammatory mediators like myeloperoxidase (MPO) are released 12

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For the re-IP experiments, PC-3 cells were obtained in culture, transfected with FLAG, FLAG-SP1 in the cells and then subjected to immunoprecipitation experiments