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Increased H 2 O 2 production following MnSOD2 expression has been linked to reduced apoptosis and cell proliferation, as well as increased angiogenesis and cell migration pathways 128 (Fig

They are not only involved in fundamental cellular functions like DNA synthesis and FeS cluster transfer in both pro- and eukaryotes, but also in the regulation of different key proteins that coordinate cellular processes (for reviews see e.g 3,4 .)