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Classification and functional annotation of metabolites were performed based on the Human Metabolome Database (HMDB, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database ( Partial least squares discrimination analysis (PLS-DA) was employed to identify differentially abundant metabolites between groups, utilizing the opls function with parameters orthoI=0 from the ropls R package (v1.34)

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10.3390/ijms24043293 21 LiL.-Y.ZhangC.-T.ZhuF.-Y.ZhengG.LiuY.-F.LiuK.et al (2022)

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