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Increases in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid

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Parallel to the new medications being developed blood transfusions with normal red blood cells, remain an effective and increasing therapeutic option for managing and preventing SCD complications, but this strategy has limitations (not uniformly accessible, accompanied by risks of alloimmunization, hemolytic transfusion reactions and transfusional iron overload)

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Clinically, various oxygen therapiesincluding hyperbaric and high-flow oxygen treatmentsnot only improve tissue oxygenation but may also reprogram redox dynamics, influence antioxidant defenses, and indirectly modulate ROS signaling pathways

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