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Despite succinates critical role in cell signaling, an accumulation, often caused by the inactivation of succinate dehydrogenase (SDH), has been associated with a pro-inflammatory state (Martnez-Reyes and Chandel, 2020)

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This forms a pathogenic positive feedback looplinking iron accumulation, A/tau pathology, and ferroptosiswhich collectively exacerbate neuronal injury (Yadav et al., 2023

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