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2.6.4 Molecular docking The crystal structure of the Receptor for Advanced Glycation End Products (RAGE) protein was retrieved from the PDB database (PDB ID: 6xq1) and preprocessed as follows: (1) removal of water molecules, ions, and native ligands using PyMOL 2.5.2

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For intrahepatic cholangiocarcinoma, saikosaponin D could reverse epinephrine- and norepinephrine-induced gemcitabine resistance by controlling glucose metabolism and drug efflux via downregulating 2-adrenergic receptor (ADRB2)/glycolysis pathway [268]

These results suggest that SLC25A39 is required specifically for the maintenance of mitochondrial GSH pools

thaliana were described in vitro to bind various ligands such as lumichrome, harmane, norharmane, indole-3-aldehyde, camalexin, and quercetin-3-O-rhamnoside (Dixon et al., 2011a) but the physiological significance remains unknown

doi: 10.1152/ajprenal.1982.242.5.F484