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Overall, further clinical trials in humans are necessary to demonstrate that dietary interventions can simultaneously influence the microbiome, intestinal permeability, inflammation, and neurocognitive symptoms, making them a compelling complementary strategy in the treatment of ME/CFS [10, 11, 13]

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combined use could intensify these symptoms, though this is theoretical in the absence of clinical data

Increasing evidence now establishes non-coding RNAs (ncRNAs) such as microRNAs, long non-coding RNAs, PIWI-interacting RNAs, and novel circular RNAs as pivotal orchestrators of this intricate system

Mice were randomly assigned to one of two groups: a vehicle control group (V-CNT) and a B12-supplemented group (SUPP)