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doi:10.1007/s00330-008-0977-y Sieber MA, Pietsch H, Walter J, Haider W, Frenzel T, Weinmann HJ (2008b) A preclinical study to investigate the development of nephrogenic systemic fibrosis: a possible role for gadolinium-based contrast media

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Further investigation revealed hesperetin's ability to decrease expression of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL), two critical mediators of necroptosis pathways, suggesting its capacity to ameliorate DSS-induced intestinal inflammation through suppression of the RIPK3/MLKL necroptosis signaling cascade (67)