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rare but serious reactions include allergic responses

The two compounds act through entirely different mechanisms, which is why research discussions treat them as complementary tools rather than interchangeable alternatives

The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with cisplatin are vomiting, neutropenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation

doi: 10.1021/acsnano.8b09573

These injections are administered subcutaneously, typically once weekly, and are intended to be used alongside lifestyle modifications including reduced-calorie diet and increased physical activity

I would just say, we dont have great information yet about how well commercial tests can tell us about protection based on the level of antibodies