doi: 10.1016/S0163-7258(98)00014-X 382
These findings underscore the notion that an integrated antioxidant system protect against biological membrane damage caused by excessive lipid peroxidation
indica pulp extract, doses ranging from 900 to 4,500 mg/kg caused no mortality
Methods Compounds for high-throughput screening For the similarity search and expanded screening, a diverse library of small-molecule compounds (1,000,000) from Asinex, Enamine and in-house collection was used
Potential mechanisms being explored include: Reduction in pro-inflammatory cytokines Antioxidant enzyme support Reduction in oxidative tissue damage Improved tissue healing environment This is one reason GHK-Cu has become so popular in regenerative and longevity medicine
The authors of the study wrote that the potential mechanisms behind these effects include "L-carnitine's role in transporting fatty acids across mitochondrial membranes, enhancing beta-oxidation, reducing free fatty acid availability, and inhibiting cholesterol synthesis." In addition, the authors noted, "L-carnitine exhibits antioxidant and anti-inflammatory properties, which can further modulate dyslipidaemia (the imbalance in blood lipids) and protect LDL from oxidative stress." Finally, it was reported that L-carnitine was able to reduce the conversion of free fatty acids to triglycerides, and ultimately prevent the build-up of triglycerides
