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10.1073/pnas.1221075110 76 MikhalyovI.SamsonovA

Kava extracts and kavalactones generally displayed negative results in genetic toxicology assays although there is sufficient evidence for carcinogenicity in experimental animals, most likely through a non-genotoxic mode of action

Krishnamurthy K, Vedam K, Kanagasabai R, Druhan LJ, Ilangovan G (2012) Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart