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Bleomycin-induced skin fibrosis in mice was similarly accompanied by upregulation of CD38 (Fig

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a , b , WT macrophages were incubated with conditioned media from senescent (CM-SEN) and non-senescent (CM-NS) mouse pre-adipocytes for 20 hours

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The beneficial effects associated with reduced CD38 function can be primarily attributed to the consequent increase in NAD + levels and sirtuin activity