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And, uh, your, you first start to get, your insulin levels start to [00:13:00] elevate, and then you start to get insulin resistance, and then your glucose itself will start to elevate and they get pre-diabetes

doi: 10.3389/fnins.2018.00073 132 DuringMJCaoLZuzgaDSFrancisJSFitzsimonsHLJiaoXet al

In this study, we identified a metabolically dysfunctional subset of disease-associated CD38-expressing CD4 + T cells before symptom onset in AD which, when targeted in 5xFAD mice, resulted in an improvement of metabolic fitness and cognition

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Furthermore, women tend to show greater cognitive resilience in preclinical stages, followed by a disproportionately accelerated cognitive decline and neurodegeneration after the onset of MCI and dementiaresulting in more severe multidomain impairment than men despite comparable amyloid burden (213, 218221)

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