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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

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Pour les cas frustes, on attachera aussi de l'importance aux points suivants : prsence de mgaloblastes dans le sang priphrique (rarement abondants) et surtout dans la moelle osseuse