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Over the past few decades, there has been a growing interest in understanding the neurobiological underpinnings of glutamatergic dysfunctions in the pathogenesis of depressive disorders and the development of new pharmacological and non-pharmacological treatment options

In this regard, calpain activity can be elevated by a sustained increase in free calcium in the cytosol and/or a decrease in calpastatin levels (127)

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VIC can also destabilize amyloid fibers, thus being a protective factor against fiber cytotoxicity

Furthermore, through a pragmatic, randomized, parallel-controlled clinical study, we confirmed that NAC supplementation with sequential LE/uFSH significantly improved clinical pregnancy outcomes in patients undergoing OI

Statistical methods All statistical analyses were performed, and all data figures were created using PRISM GraphPad version 9.1.2 (La Jolla, USA) unless otherwise specified