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1989), causing the formation of ROS and toxic effects on brain area (Kaur et al

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Ferrostatin-1 significantly mitigated these effects suggesting that lipid peroxidation drives this state

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A study involving 20 men has found that 8-week aerobic exercise (treadmill training, 40 min, 3 times/week) significantly decreases serum ROS and neuron-specific enolase (NSE) levels, and increased SOD activity and brain-derived neurotrophic factor (BDNF) levels while improving body composition parameters in obese individuals, indicating that exercise can exert beneficial effects through improving the oxidant-antioxidant imbalance disrupted by obesity, elevating levels of neurotrophic factors, and limiting blood-brain barrier dysfunction [180]