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Elevated levels of CSN5 subsequently regulate programmed cell death 1 ligand 1 (PD-L1) stability in cancer cells by modulating its deubiquitination ( Dyslipidemia induced in mice by a diet high in fat and cholesterol significantly reduced dendritic cell activation in mice tumor microenvironment

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Another interesting compound, quercetin, has been shown to inhibit the activity of CD38 by binding to its active site, which results in increased intracellular NAD + 143

Collectively, these findings establish a novel mechanistic link between AIBP and hepatic lipid homeostasis, wherein AIBP deficiency exacerbates metabolic dysregulation and inflammation through ITG3-dependent PI3K/AKT pathway activation