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Due to their high efficacy, many ototoxins are still used despite the risk of hearing loss

10.1016/s0969-2126(99)80026-4 3 BouatraS

Furthermore, we found that chronic hypoxia enhanced ceramide catabolism by inducing hypoxia-inducible factor (HIF)-2 and HIF-2-dependent transcriptional activation of alkaline ceramidase 2 (Acer2)

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Distinct regulatory profile compared to sedative agents: Conventional sedatives typically enhance inhibitory neurotransmission directly, often suppressing neural activity broadly

Researchers may also evaluate cagrilintide alongside GLP-1 receptor agonists in combination study designs to explore potential interactions in appetite and weight regulation models