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Normal aging is accompanied by a decline in cerebral metabolism, driven by impaired mitochondrial ATP production, increased reactive oxygen species (ROS), and decreased antioxidant defenses (Maldonado et al., 2023), and these deficits are amplified in ADRD compared to cognitively normal older adults (Patro et al., 2021

Janus silica nanoparticle-based tumor microenvironment modulator for restoring tumor sensitivity to programmed cell death ligand 1 immune checkpoint blockade therapy

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PMID: 22354407

It is important to note that S1P is considered a tumor-promoting lipid due to its impact on autophagy, and increased S1P levels have been identified as a drug-resistance mechanism in some cancer types

Ziyi Guo, Dr