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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

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The new results from REDEFINE-1 show that cagrilintide can help people lose a meaningful amount of weight and is generally well tolerated

Consequently, exposure to CPA leads to enzymatic cleavage of the C-terminal end of albumin, reducing its binding to FcRn, as previously reported 60

The residual enzyme activity does not correlate with the subsequent disease course

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